Teko e bonts'itse sekhahla se phahameng sa li-disinfectants tsa quaternary ammonium e le kalafo ea livaerase tse ngata, ho kenyeletsoa li-coronaviruse: tsena li sebetsa ka ho koala lesela le sireletsang la lipid le apesitseng vaerase joalo ka SARS-CoV-2.Metsoako ea quaternary ammonium e khothaletsoa hohle ho bolaea livaerase mme ho na le lihlahisoa tse fetang 350 Lethathamong la N la EPA: Likokoana-hloko tse sebelisoang khahlano le SARS-CoV-2 (Supplementary Material. lik'hemik'hale tse lethathamong la EPA li tlalehiloe 'me> 140 e ka tima kokoana-hloko ka metsotso e seng mekae feela (18).
Tlhahisoleseding ena e ile ea re lebisa patlisisong e kholoanyane ea metsoako ea quaternary ammonium e nang le ts'ebetso e khahlano le coronavirus le ho tsebahatsa lik'hemik'hale tse seng li lekiloe tleliniking mme li ka sebelisoa e le kalafo e ka bang teng bakeng sa COVID-19.E 'ngoe ea lintho tse bolaeang likokoana-hloko tse bontšitsoeng li senya likokoana-hloko (Supplementary Material) 'me li sebelisoa haholo lihlahisoa tsa tlhokomelo ea motho ke cetylpyridinium chloride.Motsoako ona o fumanoa haholo ka lihlatsoa molomong 'me o thathamisitsoe ke FDA e le Kakaretso e Nkoang e Sireletsehile (GRAS) hoo e boetse e sebelisoa e le moriana o thibelang likokoana-hloko bakeng sa nama le lihlahisoa tsa likhoho (ho fihla ho 1%).Cetylpyridinium chloride e sebelisitsoe litekong tse ngata tsa bongaka, ho kenyeletsoa joalo ka kalafo khahlano le tšoaetso ea phefumoloho e netefatsang ts'ebeliso ea eona joalo ka antiviral.Cetylpyridinium e ka 'na ea khothalletsa ts'ebetso ea kokoana-hloko ka ho senya capsid hammoho le ketso ea eona ea lysosomotropic, eo, joalokaha ho boletsoe ka holimo, e tloaelehileng bakeng sa metsoako ea quaternary ammonium.Sena se hlahisa potso ea hore na litlhare tse ling tse tšoailoeng ka ts'ebetso ea antiviral khahlano le SARS-CoV-2 in vitro li sebetsa ka mokhoa o ts'oanang, e leng hore li ka senya kokoana-hloko ea capsid le ho bokellana ho lysosome kapa endosomes mme qetellong ea thibela ho kena ha kokoana-hloko.Liphuputso tse ling tse hatisitsoeng li bontšitse hore phello ena e ka fokotsoa ke tšebeliso ea Cathepsin-L inhibitors.
Cetylpyridinium chloride (CPC)
Quaternary ammonium metsoako e nang le ts'ebetso e tsebahalang ea coronavirus
| Molek'hule | Ts'ebetso ea antiviral | Mokhoa | FDA e amohetsoe | Lisebelisoa |
| Ammonium Chloride | Murine coronavirus, lefu la sebete la C, | Lysosomotropic | Ee | Lisebelisoa tse fapaneng tse kenyelletsang metabolic acidosis. |
| Cetylpyridinium chloride | Influenza, hepatitis B, kokoana-hloko ea polio 1 | Liphoofolo tsa capsid 'me ke lysosomotropic | Ho joalo, GRAS | Antiseptic, sehlatsoa molomo, litlolo tsa ho khohlela, lihlahisoa tsa tlhokomelo ea motho, lisebelisoa tsa ho hloekisa joalo-joalo. |
Nako ea poso: Aug-03-2021