Olivetol, e tsejoang hape e le 5-pentylresorcinol, ke motsoako oa tlhaho o fumaneng tlhokomelo e kholo lilemong tsa morao tjena bakeng sa ts'ebeliso ea ona ea meriana le indasteri.Ke molek'hule e tlang pele bakeng sa biosynthesis ea metsoako e fapaneng, ho kenyeletsoa li-cannabinoids tse fumanoang haholo semeleng sa cannabis.Ho utloisisa biosynthesis eamohloaareHo bohlokoa ho hlokomela bokhoni ba eona le ho hlahloba ts'ebeliso ea eona e fapaneng.
The biosynthesis eaOlivetole qala ka condensation ea limolek'hule tse peli tsa malonyl-CoA, tse tsoang ho acetyl-CoA, ka ketso ea enzyme e bitsoang polyketide synthase.Karabelo ena ea condensation e lebisa ho thehoeng ha motsoako o mahareng o bitsoang geranyl pyrophosphate, e leng selelekela se tloaelehileng ho biosynthesis ea lihlahisoa tse fapaneng tsa tlhaho, ho kenyeletsoa terpenes.
Geranyl pyrophosphate e ntan'o fetoloa asiti ea mohloaare ka letoto la karabelo ea enzymatic.Mohato oa pele o kenyelletsa ho fetisetsa sehlopha sa isoprenyl ho tloha geranyl pyrophosphate ho molek'hule ea hexanoyl-CoA, ho etsa motsoako o bitsoang hexanoyl-CoA olive acid cyclase.Karabelo ena ea cyclization e hlahisoa ke enzyme e bitsoang hexanoyl-CoA: olivelate cyclase.
Mohato o latelang ho kenamohloaarebiosynthesis e kenyelletsa phetoho ea hexanoyl-CoA olivetate cyclase hore e be sebopeho se sebetsang se bitsoang tetraketide intermediate.Sena se finyelloa ka letoto la karabelo ea enzymatic e hlahisoang ke li-enzyme tse kang chalcone synthase, stilbene synthase, le resveratrol synthase.Boitšoaro bona bo lebisa ho thehoeng ha li-intermediate tsa tetraketide, tse fetoletsoeng ho olivetol ka ketso ea polyketide reductase.
Hangmohloaaree entsoe, e ka fetoloa ka ho eketsehileng ka metsoako e sa tšoaneng, ho akarelletsa le cannabinoids, ka ketso ea li-enzyme tse kang cannabidiolic acid synthase le delta-9-tetrahydrocannabinolic acid synthase.Li-enzyme tsena li etsa hore ho be le condensation eamohloaareka geranyl pyrophosphate kapa limolek'hule tse ling tse tlang pele ho etsa li-cannabinoids tse fapaneng.
Ntle le karolo ea eona ho cannabinoid biosynthesis,mohloaaree fumanoe e na le thepa ea antifungal le antioxidant e ka bang teng.Liphuputso li bontšitse seomohloaaree ka thibela kholo ea mefuta e fapaneng ea likokoana-hloko tsa fungal, e etsa hore e be mokhethoa ea tšepisang bakeng sa nts'etsopele ea lithethefatsi tsa antifungal.Ho feta moo,mohloaaree 'nile ea bontšoa hore e na le ts'ebetso e matla ea ho senya khahlanong le li-radicals tsa mahala, e leng limolek'hule tse sebetsang haholo tse ka bakang tšenyo ea lisele le lisele.Thepa ena ea antioxidant eamohloaaree fana ka maikutlo a ts'ebeliso ea eona e ka bang teng ho nts'etsapele lisebelisoa tsa kalafo bakeng sa kalafo ea mafu a amanang le khatello ea kelello ea oxidative.
Ka kakaretso, biosynthesis eamohloaaree kenyelletsa condensation ea limolek'hule tsa malonyl-CoA, e lateloa ke letoto la karabelo ea enzymatic, e hlahisang sebopeho samohloaare.Motsoako ona o sebetsa e le molek'hule oa pele ho biosynthesis ea cannabinoids hammoho le lihlahisoa tse ling tsa tlhaho.Ho utloisisa tsela ea biosynthetic eaOlivetole bohlokoa ho nts'etsapele ts'ebeliso ea eona e ka bang teng mafapheng a meriana le a indasteri.Lipatlisiso tse ling mabapi le biosynthesis eamohloaare'me lihlahisoa tsa eona li ka lebisa ho sibolloeng ha metsoako e mecha ea phekolo le ho thusa ho hlahisa meriana e mecha.
Nako ea poso: Nov-13-2023